NI-57 - BRPF Bromodomain Inhibitor. CAS# 1883548-89-7 Catalog No.:M60279-10S and insulin-like growth factor 1

and insulin-like growth factor 1 (IGF-1)

6(7):966-7

BRD3 and BRD4 with IC50 of 10-19 nM

6-dichloro-1H-indole-3-propanoic acid

CO-1686 potently and selectively inhibits growth of NSCLC cells expressing mutant EGFR and induces apoptosis

NI-57 - BRPF Bromodomain Inhibitor. CAS# 1883548-89-7 Catalog No.:M60279-10S and insulin-like growth factor 1NI 57, CAS No. 1883548 89 7, is a potent and selective inhibitor of the bromodomain of the BRPFs. It binds to BRPF1B with a KD of 31 nM (ITC), to BRPF2 with a KD of 108 nM (ITC) and to BRPF3 KD of 408 nM (ITC). NI 57 is very selective against other non Class IV bromodomains, including the BETs, has minimum 32 fold selectivity against BRD9. It shows accelerated FRAP recovery at 1 M in the BRPF2 FRAP assay preventing binding of full length BRPF2 to