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SC-514 dose-dependently inhibits RANKL-induced osteoclastogenesis and induced apoptosis and caspase 3 activation in RAW264
Mitoxantrone
with a mean IC50 of 230 nM
24 hours) decreases colony formation in MCF-7 cells
(2013) Cell Stem Cell
Bisindolylmaleimide IV - CAS# 119139-23-0 60129 SC-514 dose-dependently inhibits RANKL-induced osteoclastogenesisBisindolylmaleimide IV, CAS No. 119139 23 0, is an inhibitor of pyruvate phosphate dikinase (PPDK). Product information CAS Number: 119139 23 0 Molecular Weight: 327. 34 Formula: C20H13N3O2 Chemical Name: 3,4 Bis(1H indol 3 yl)pyrrole 2,5 dione Smiles: O=C1NC(=O)C(=C1C1=CNC2=CC=CC=C21)C1=CNC2=CC=CC=C21 InChiKey: DQYBRTASHMYDJG UHFFFAOYSA N InChi: InChI=1S C20H13N3O2 c24 19 17(13 9 21 15 7 3 1 5 11(13)15)18(20(25)23 19)14 10 22 16 8 4 2 6 12(14)16 h1