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In vitro: Cytochalasin J was identified as a deacetylated analog of cytochalasin H that weakly inhibited actin assembly but significantly altered mitotic spindle microtubule organization and kinetochore structure
this agent is highly polyglutamylated and competes for the folate binding site of DHFR
Iadademstat reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL
PAH) is not influenced by Nourseothricin
Formula: C28H48O2
LY 2389575 hydrochloride 17454 In vitro: Cytochalasin J wasLY2389575 is described here instead of LY2389575 hydrochloride. LY2389575 is a selective negative allosteric modulator (NAM) of metabotropic glutamate receptor 3 (mGlu3) with an IC50 value of 4. 2 M . The metabotropic glutamate receptors (mGlus) are members of the GPCR family C. They are characterized by a large extracellular amino terminal domain for binding agonist. Eight mGlus had been found and were assigned to three groups based on their