CH5424802 Catalog No.:M10732-2 Chemical Name: (2S)-2-[(2-benzoylphenyl)amino]-3-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)propanoic acid

Chemical Name: (2S)-2-[(2-benzoylphenyl)amino]-3-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)propanoic acid

Smiles: CC1=CC=C(C=N1)C1=NC=C(Cl)C=C1C1C=CC(=CC=1)S(C)(=O)=O

PubMed PMID: 27334838

1007/s00280-009-1140-4

acetylcholine and glutamate evoked firing of rat cerebral cortical neurons

CH5424802 Catalog No.:M10732-2 Chemical Name: (2S)-2-[(2-benzoylphenyl)amino]-3-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)propanoic acidAlectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4 ALK fusion and anaplastic large cell lymphoma (ALCL) cells expressing NPM ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which