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Metarrestin blocks metastatic development and extends survival in mouse cancer models
Smiles: CC(C)[C@H](O)C(=O)N[C@@H](C)C(=O)N[C@H]1C2=CC=CC=C2CCN(C)C1=O
PubMed PMID: 26810834
Seiwert SD
Chemical Name: 6-propyl-2-sulfanylidene-1
Tenovin 6 Hydrochloride Catalog No.:M9044-10 Metarrestin blocks metastatic development andTenovin 6, also known as Tnv 6, is a bioactive small molecule SIRT2 inhibitor with anti neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro apoptotic effects of Tnv 6 in many tumors. Tnv 6 causes non genotoxic cytotoxicity, without adversely affecting human clonogenic hematopoietic progenitors in vitro, or murine hematopoiesis. Mechanistically, exposure of CLL cells to
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