Tankyrase Inhibitors (TNKS) 22 halin Smiles: CN1C=C(C2=C(C3=CN(C4CCN(CC5=CC=CC=N5)CC4)C4=CC=CC=C34)C(=O)NC2=O)C2=CC=CC=C12

Smiles: CN1C=C(C2=C(C3=CN(C4CCN(CC5=CC=CC=N5)CC4)C4=CC=CC=C34)C(=O)NC2=O)C2=CC=CC=C12

AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6

inhibitor of the F0 part of H+-ATP-synthase

Formula: C77H96ClF3N10O10S4

CD38-IN-78c

Tankyrase Inhibitors (TNKS) 22 halin Smiles: CN1C=C(C2=C(C3=CN(C4CCN(CC5=CC=CC=N5)CC4)C4=CC=CC=C34)C(=O)NC2=O)C2=CC=CC=C12Tankyrase Inhibitors (TNKS) 22 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis