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HM-JF526 NHS
selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling
CAS Number: 2070018-29-8
Tetramethylcurcumin (FLLL31
0003 micromol/L)
Cinobufagin en-d5 HM-JF526 NHSCinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti liver cancer. IC50 value: Target: In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0. 1, 1, or 10 M after 24 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24 hr culture as well as caspase 3
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