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Neochlorogenic acid (NCA) shows a reduction of lipopolysaccharide (LPS)-induced NO production by suppressing iNOS and COX-2 protein expression and production of pro-inflammatory cytokines
but appeared to enhance LPS-induced secretion of IL-8 in PHM1-41 cells
) dose-dependently decreases water consumption in water deprived rats
InChiKey: MJRWWLRDMAXCFR-UHFFFAOYSA-N
37(1):193-200
IRAK4-IN-6 - CAS# 2454244-02-9 nanthrene Neochlorogenic acid (NCA) shows aIRAK4 IN 6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma. Product information CAS Number: 2454244 02 9 Molecular Weight: 504. 59 Formula: C25H32N10O2 Chemical Name: methyl 4 [(1r,4r) 4 {[6 (cyanomethyl) 2 [(1 methyl 1H pyrazol 4 yl)amino]pyrido[3,2 d]pyrimidin 4 yl]amino}cyclohexyl]piperazine 1 carboxylate Smiles:
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