![Ro 48-8071 fumarate - CAS# 189197-69-1 Size:Solid 10 mg Chemical Name: 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochloride](https://cdn.shopify.com/s/files/1/0389/1897/9723/files/1686725394423.png?v=1686725414)
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Chemical Name: 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochloride
5]nonan-2-yl)pyrimidin-5-yl)oxy)benzamide
1056901-67-7 (R-isomer)
CNS distribution
Quetiapine S-oxide
Ro 48-8071 fumarate - CAS# 189197-69-1 Size:Solid 10 mg Chemical Name: 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochlorideRo 48 8071 is an orally active cholesterol synthesis inhibitor or a 2,3 oxidosqualene: lanosterol cyclase (OSC) inhibitor. OSC (EC 5. 4. 99. 7) represents a unique target for a cholesterol lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG CoA reductase expression, generating a synergistic, self limited negative regulatory loop.
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