10058-F4 Size:Solid 2 mg highly potent and selective BMP

highly potent and selective BMP pathway inhibitor by inhibiting BMP type I receptors ALK2 (IC50=5 nM) and ALK3 (IC50=30 nM)

is a potent and selective small molecule to activate both Oct4 and Nanog promoter-driven luciferase reporter genes

and has no effect on PKCζ (IC50

PubMed PMID: 31810959

1-8H3/t25-

10058-F4 Size:Solid 2 mg highly potent and selective BMP10058 F4 is a potent and selective c Myc inhibitor, which markedly increases valproic acid induced cell death in Jurkat and CCRF CEM T lymphoblastic leukemia cells. 10058 F4 inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. 10058 F4 induces cell cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Product information CAS