AEE788 60258 and 25 mg/kg prolongs median

and 25 mg/kg prolongs median survival to 19

Molecular Weight: 530

5 mg/kg) reduces tumor growth in HCT116 and HT29 mouse xenograft models as well as platinum-resistant and -sensitive high-grade serous ovarian cancer patient-derived xenograft (PDX) mouse models

Fujimori A

InChiKey: ISWRGOKTTBVCFA-VIQYUKPQSA-N

AEE788 60258 and 25 mg/kg prolongs medianAEE 788 is an orally bioavailable multiple receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor associated endothelial cell apoptosis. Check for