Some commanders are very intuitive, like Krenko, Mob Boss
Infect is an obvious strategy, and I may someday rebuild her as an infect deck, but I had been playing a lot of Brion Stoutarm lately and had really enjoyed the life gain he gives
Splinter Twin pairs with creatures like Deceiver Exarch to make an endless stream of hasty tokens, and for years that combo control shell was one of the main pillars of Modern
The fact that is has means that supply is likely way higher than initially thought which is why these prices are dropping so fast
Cheap legendary creatures, like Skrelv, Defector Mite and Lotho, Corrupt Shirriff are also great for this
From there you can play Pillar of Zeiros to banish all dead minions and heal 1 life for each