PF-4136309 - CAS# 1341224-83-6 273 Torin-1 did not affect the

Torin-1 did not affect the survival of normal colon stem cells in vivo

453 produces sustained responses in a similar concentration range to those observed with acute stimulation (a small 1

PubMed Central PMCID: PMC5777092

and FGFR4 with IC50=60 nM

is a selective LIM kinase 2 (LIMK2) inhibitor

PF-4136309 - CAS# 1341224-83-6 273 Torin-1 did not affect thePF 4136309, CAS No. 1341224 83 6, also known as INCB8761, is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF 04136309 specifically binds to CCR2 and prevents binding of the endothelium derived chemokine ligand CLL2 (monocyte chemoattractant protein 1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2