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Solubility: DMSO : 14 mg/mL (102
210 μg×h/mL
WAY-200070 (30 mg/kg s
Molecular Weight: 1347
which are responsible for Src and Ras/MAPK signaling respectively
PF-06463922 5109 HCl Solubility: DMSO : 14 mg/mLLorlatinib, also known as PF 06463922, is an orally available, ATP competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C ros oncogene 1 (Ros1), with potential antineoplastic activity. Upon administration, ALK ROS1 inhibitor PF 06463922 binds to and inhibits both ALK and ROS1 kinases. The kinase inhibition leads to disruption of ALK and ROS1 mediated signaling and eventually inhibits tumor cell growth in ALK and
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