BI-3663, PTK2/FAK PROTAC 632 Smiles: CN1CCN(CC1)C1=CC=C(C=C1NC(=O)C1=CC(=CC=C1)OC)C(=O)OC

Smiles: CN1CCN(CC1)C1=CC=C(C=C1NC(=O)C1=CC(=CC=C1)OC)C(=O)OC

17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)acetonitrile

4R)-1-((S)-2-(2-(2-(2-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)ethoxy)ethoxy)acetamido)-3

InChiKey: ZXOBLNBVNROVLC-UHFFFAOYSA-N

Roberts BJ

BI-3663, PTK2/FAK PROTAC 632 Smiles: CN1CCN(CC1)C1=CC=C(C=C1NC(=O)C1=CC(=CC=C1)OC)C(=O)OCBI 3663 is a highly selective PTK2 FAK PROTAC (DC50=30 nM), with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI 3663 inhibits PTK2 with an IC50 of 18 nM. BI 3663 is a PROTAC that composes of BI 4464 (HY 124625) linked to Pomalidomide (HY 10984) with a linker. Anti cancer activity. Product information CAS Number: 2341740 84 7 Molecular Weight: 917. 84 Formula: C44H42F3N7O12 Chemical Name: N [2 (2, 6 dioxopiperidin 3 yl) 1, 3 dioxo 2, 3