Sorafenib Tosylate - CAS# 475207-59-1 rizine dihydrochloride Smiles: OC1C=C2OC3C=C(O)C=CC=3C3(OC(=O)C4=CC(=CC=C34)C(=O)ON3C(=O)CCC3=O)C2=CC=1

Smiles: OC1C=C2OC3C=C(O)C=CC=3C3(OC(=O)C4=CC(=CC=C34)C(=O)ON3C(=O)CCC3=O)C2=CC=1

Chemical Name: N-(5-(4-((1

with IC50 and KD values close to or below 1 nM as well as a slow dissociation rate

2095432-75-8

Formula: C35H49N11O9S2

Sorafenib Tosylate - CAS# 475207-59-1 rizine dihydrochloride Smiles: OC1C=C2OC3C=C(O)C=CC=3C3(OC(=O)C4=CC(=CC=C34)C(=O)ON3C(=O)CCC3=O)C2=CC=1Sorafenib, also known as BAY 43 9006, is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF MEK ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR 2 PDGFR beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer. Product