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Ivosidenib (racemic)
including colorectal (HCT-116)
Epub 2012 Jun 15
2% Tween 80) in the other animal studies
apoptosis and enhanced sensitivity to ionizing radiation
Mitoxantrone - CAS# 65271-80-9 035 Ivosidenib (racemic)Mitoxantrone, CAS No. 65271 80 9, is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5. 3 M), thus inhibiting cell proliferation. It also inhibits HIV 1 integrase (IC50 = 3. 8 M). Mitoxantrone is exported from cells in an ATP and glutathione dependent manner by multidrug resistance protein 1. 4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis. Product information CAS