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GLPG0187 dose-dependently diminishes the size of the aldehyde dehydrogenase high subpopulation of prostate cancer cells
Chemical Name: 1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea
Formula: C11H14N2O4
CAS Number: 2070015-10-8
is a cereblon ligand with alkyl linker and terminal acid for onward chemistry
L-2-Hydroxyglutaric acid disodium 0302 GLPG0187 dose-dependently diminishes the sizeL 2 Hydroxyglutaric acid disodium ((S) 2 Hydroxyglutaric acid disodium, L 2 Hydroxyglutarate disodium, LGA, L 2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L 2 Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi CK) with Km and Ki of 2. 52 mM and 11. 13 mM, respectively. Product information CAS Number: 63512 50
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