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Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
Chemical Name: 2-(1
suppresses lung cancer cell proliferation and inhibits tumor growth in vivo
52029-86-4
but does not exert mitotic arrest in HeLa cells
HTH-01-015 - CAS# 1613724-42-7 Catalog No.:M6435-10 Chemical modulation of chaperone-mediated autophagyHTH 01 015, CAS No. 1613724 42 7, is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. The administration of HTH 01 015 to MEFs (mouse embryonic fibroblasts) significantly inhibits migration in a wound healing assay to a similar extent as NUAK1 knockout. HTH 01 015 also inhibit proliferation of MEFs to the same extent as NUAK1 knockout
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