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67)68)24-44(46(36)38)86(78
Formula: C18H28NO4P
targets mutant FLT3 and is currently in late-stage clinical trials
Smiles: OC1=C(C(=O)NC2=CC(Cl)=CC=C21)C1C=C(C=CC=1)OC1C=CC=CC=1
6-dichlorophenoxy)methyl]phenyl}methoxy)-4-methoxybenzene
ATC 0175 hydrochloride 2927 67)68)24-44(46(36)38)86(78ATC0175 hydrochloride is a potent, selective and orally active antagonist of melanin concentrating hormone receptor 1 (MCH1) with IC50 of 13 nM for MCH1. It was also shown to have affinity for 5 HT2B and 5 HT1A receptors with IC50 of 9. 66 nM and 16. 9 nM respectively. Melanin concentrating hormone receptor (MCH1), a member of the G protein coupled receptor family 1, is an integral plasma membrane protein which binds melanin concentrating hormone. The
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