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76(24):7130-7139
InChi: InChI=1S/C63H116O15/c1-4-7-10-31-40-57(64)43-34-25-19-13-16-22-28-37-46-73-61(67)76-51-49-70-55-60(72-53-54-78-63(69)75-48-39-30-24-18-15-21-27-36-45-59(66)42-33-12-9-6-3)56-71-50-52-77-62(68)74-47-38-29-23-17-14-20-26-35-44-58(65)41-32-11-8-5-2/h25-27
phenserine
Metalnikov P
66 µM and 7
S2157 rrin 76(24):7130-7139S2157, a N alkylated tranylcypromine (TCP) derivative, is a potent lysine specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super enhancer regions. S2157 induces apoptosis in TCP resistant T cell acute lymphoblastic leukemia (T ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood brain barrier and can almost completely eradicate CNS
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