![CCG-1423 Catalog No.:M9362-10 Smiles: C[C@@H]1CC2=C(NC3=CC=CC=C32)[C@@H](C2C(F)=CC(=CC=2F)/C=C/C(O)=O)N1CC(C)(C)F](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M9362_1621560099.gif?v=1621560100)
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Smiles: C[C@@H]1CC2=C(NC3=CC=CC=C32)[C@@H](C2C(F)=CC(=CC=2F)/C=C/C(O)=O)N1CC(C)(C)F
which suggests a positive impact of the HDAC inhibitor on pulmonary vascular remodeling and stiffening
PubMed Central PMCID: PMC6631818
Degenhardt Y
also known as Gastromiro and SQ-13396
CCG-1423 Catalog No.:M9362-10 Smiles: C[C@@H]1CC2=C(NC3=CC=CC=C32)[C@@H](C2C(F)=CC(=CC=2F)/C=C/C(O)=O)N1CC(C)(C)FCCG 1423 is a small molecule inhibitor of RhoA transcriptional signaling. CCG 1423 displays activity in several in vitro cancer cell functional assays. CCG 1423 potently (<1 mumol L) inhibits lysophosphatidic acid induced DNA synthesis in PC 3 prostate cancer cells, and whereas it inhibits the growth of RhoC overexpressing melanoma lines (A375M2 and SK Mel 147) at nanomolar concentrations, it is less active on related lines (A375 and SK Mel 28) that
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